r/longevity • u/lunchboxultimate01 • Jan 01 '26
With global average life expectancy at 73 years, age-related ill health is the main driver of healthcare costs, loss of independence, and disability in most countries. Although human biology is complex and there are hundreds of age-related pathologies, the biology of aging can be categorized into a much smaller number of categories and potential treatments. Medically intervening in aspects of aging biology has the potential to increase healthy lifespan in humans and ameliorate, prevent, or reverse age-related health decline and disability.
The umbrella term "longevity" covers a wide range of interests from simple lifestyle advice to hypothetical biomedical rejuvenation to significantly increase healthy lifespan. Beware, as "longevity" is also readily used by quacks and grifters who promote and sell unproven treatments. Because so many subs cover lifestyle (diet, exercise, etc.), it is not allowed in posts here. For those interested in lifestyle, two useful resources are the free substacks of Dr. Eric Topol and Dr. Christin Glorioso, (choose "No thanks" if you don't want to provide your email).
The focus of this sub is biomedical research targeting aspects of the biology of aging, including medical interventions that aim to go through clinical trials and regulatory approval. Continue reading for examples.
Table of Contents
Introductory presentations to the field
Introductory academic papers
Ethical arguments
University labs around the world
For those interested in pursuing advanced degrees in the field, this Google Sheet is several years old but is a good starting point for labs around the world.
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Below are examples of organizations and additional material. For a comprehensive website on resources and more, see https://agingbiotech.info/ maintained by angel investor and longevity advocate Karl Pfleger.
Podcasts
Video lectures and presentations
Government agencies or government-sponsored organizations
Examples of biotech companies in the field
Academic and nonprofit research organizations (please consider donating)
Ex-USA
USA
Think tanks and advocacy organizations
Ex-USA
USA
r/longevity • u/towngrizzlytown • 8h ago
Mazonakis died on 9 September after suffering a heart attack while undergoing plasmapheresis.
r/longevity • u/derrikson • 2d ago
Researchers identified PLA2G2F, an enzyme whose expression increases with age and appears to help protect the brain against age-related changes.
Boosting its activity in older mice preserved spatial memory, reduced synaptic loss and limited inflammation-related changes. Human brain samples also linked higher expression to cognitive resilience despite Alzheimer's pathology.
The findings are preclinical. Whether targeting this enzyme could help humans remains unknown.
r/longevity • u/barrel_master • 3d ago
Paper on a method to restore enamel to teeth. Some of the research was done on teeth extracted from donors.
Part of the abstract below:
Regrowth of lost enamel in tooth decay and sensitivity is a major obstacle to overcome. Here, the authors report on a protein-based material that mimics features of natural enamel formation, allowing for epitaxial growth of apatite nanocrystals to restore enamel structure and function.
r/longevity • u/lunchboxultimate01 • 3d ago
r/longevity • u/SuperBonerFart • 5d ago
r/longevity • u/towngrizzlytown • 5d ago
BIOGAMI teams will decode the “grammar” that guides how intrinsically disordered proteins (IDPs) behave and create new ways to steer misfolded or clumped (aggregated) proteins back into healthy shapes. The program focuses on the very earliest steps in the misfolding process — before proteins clump together and damage cells — especially in the brain and other vulnerable tissues. By acting early, BIOGAMI aims to stop neurodegenerative disease and other chronic diseases before they fully develop, instead of only treating symptoms after serious damage has occurred.
r/longevity • u/Slow_cpu • 6d ago
r/longevity • u/Slow_cpu • 7d ago
r/longevity • u/lunchboxultimate01 • 7d ago
ARDD 2026 recordings are being uploaded to their YouTube channel (https://www.youtube.com/@ardd3628/videos). Feel free to post individual videos you find interesting, but try to avoid reposts.
r/longevity • u/the_mit_press • 7d ago
r/longevity • u/Slow_cpu • 7d ago
r/longevity • u/Slow_cpu • 7d ago
r/longevity • u/Slow_cpu • 8d ago
r/longevity • u/barrel_master • 10d ago
r/longevity • u/towngrizzlytown • 10d ago
Finding and testing new longevity medicines, with updates on research, pharma involvement, biomarkers for human trials and the limits of AI.
r/longevity • u/Slow_cpu • 11d ago
r/longevity • u/Slow_cpu • 12d ago
r/longevity • u/towngrizzlytown • 12d ago
r/longevity • u/Livid_Parsnip_2816 • 12d ago
The peer-reviewed study identified SRSF1 through a transcriptomic screening platform; the lifespan experiment was small, with 9–10 mice per group, so the result is promising but still early.
r/longevity • u/ptword • 11d ago
r/longevity • u/Slow_cpu • 13d ago
r/longevity • u/Slow_cpu • 14d ago
r/longevity • u/fchung • 15d ago
r/longevity • u/user_-- • 15d ago
A string of longevity meetings (ARDD, Biomarkers of Aging, etc.) just wrapped up in Boston and I have to assume some folks here showed up. Please share any highlights!