An old friend sent me two clinic quotes for his mum's knee because I work in a university biology lab. Technician, I keep other people's cell lines alive, so this is roughly my area and roughly not.
One quote said SVF, from a sports clinic near her that I'm not naming because he'd know it was me posting. The other said culture-expanded mesenchymal cells from a donor. He'd googled the difference between SVF and mesenchymal stem cell therapy and read the two quotes as two prices for the same thing. They're not.
SVF is fat out, spun, injected back the same day. What goes in is a mix. Immune cells, cells from vessel walls, fibroblasts, and somewhere between a few percent and a third stromal cells depending who's counting, with the actual progenitors at the small end of that. Nobody grows anything. Upside, it's her own tissue, no freezing, no weeks of culture. Downside, they can count how many cells went in but not how many were the useful ones.
Cultured cells are the other route. Start from a donor sample, usually cord or placenta from a bank, grow it out until the mesenchymal cells take over the dish, freeze it, thaw it, sometimes grow it a bit more, check what it is, then it goes in. Upside, a defined population and a real count. Downside, someone else's cells, every extra round in culture ages them, and the checks tell you what the cells are. Whether they do anything is a different test and nobody showed me one.
The second quote was from Swiss Medica, which is the Belgrade one. Same place lists SVF too, this quote just wasn't for that. It spells out cord tissue from a bank, expanded and checked in their own lab before use, so at least the quote says what it is.
What I couldn't tell him is which fork matters more for a knee, own versus donor or same day versus grown. The papers I could find don't settle it either.
She hasn't picked. She might not. Did anyone get told why one and not the other?